Fluoride Toxicity: Overview and Examples By David Kennedy, DDS, Amanda Just, MS, Jack Kall, DMD, and Griffin Cole, DDS September 2017 Overview Fluoride Exposure, Toxicity, and Health Effects The sources of human exposure to fluoride have drastically increased since community water fluoridation began in the U.S. in the 1940’s. Sections I (Health Hazard Assessments for Noncarcinogenic Effects) and The method can be used for water containing at least 20 µg/litre (Slooff et al., 1988). Fluoride 50(4)393–408 October-December 2017 Effects of fluoride toxicity on animals, plants, and soil health: a review Shahab, Mustafa, Khan, Zahid, Yasinzai, Ameer, Asghar, Ullah, Nadhman, Ahmed, Munir, Mujahid, Hussain, Ahmad, Ahmad 394 394 Sources of F: There are many different sources of F but the main sources are the People are primarily exposed to fluoride from drinking water and use of fluoridated dental products, with water fluoridation representing 30% to 70% of a typical individual’s total exposure. IRIS assessment development process. The first sign of fluoride toxicity is dental fluorosis, which is on the rise in the USA. PDF | On Jan 1, 2012, Neha Jaiswal and others published Fluoride Toxicity | Find, read and cite all the research you need on ResearchGate Concerns for Potential Fluoride Toxicity Controversy over community water fluoridation stems from concerns about the potential harmful effects of fluoride and the ethics of water fluoridation. 2) (NRC 2006). Fluorine (soluble fluoride); CASRN 7782-41-4 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data, as outlined in the . Thus, acute toxicity (LD 50) occurred between 26 and 102 mg/kg b.w./day, and chronic toxicity (LOAEL) between 4.3 and 7.6 mg/kg b.w./day fluoride (Fig. Fluoride is usually determined by means of an ion-selective electrode, which makes it possible to measure the total amount of free and complex-bound fluoride dissolved in water. For rainwater in which fluoride was present at a concentration of 10 µg/litre, a The most commonly cited health concerns related to fluoride and water fluoridation are bone fractures and skeletal fluorosis, decreased Examples of fluoride toxicity demonstrate its serious threat. Fluoride is added to municipal water supplies and dental products, such as toothpaste, to prevent or reduce tooth decay.